Lainé, Dramane I. : rechercher sur Z-Library

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1

Design, Synthesis, and Structure−Activity Relationship of Tropane Muscarinic Acetylcholine Receptor Antagonists

Lainé, Dramane I., Wan, Zehong, Yan, Hongxing, Zhu, Chongjie, Xie, Haibo, Fu, Wei, Busch-Petersen, Jakob, Neipp, Christopher, Davis, Roderick, Widdowson, Katherine L.

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2009

2

Design, synthesis and structure–activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists

Dramane I. Lainé, Hongxing Yan, Haibo Xie, Roderick S. Davis, Jeremy Dufour, Katherine L. Widdowson, Michael R. Palovich, Zehong Wan, James J. Foley, Dulcie B. Schmidt, Gerald E. Hunsberger, Miriam Bu

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 379 KB

english, 2012

3

An Asymmetric Phase-Transfer Dihydroxylation Reaction

Riaz A. Bhunnoo, Yulai Hu, Dramane I. Lainé, Richard C. D. Brown

Journal:

Angewandte Chemie

Année:

2002

Langue:

english

Fichier:

PDF, 57 KB

english, 2002

4

An Asymmetric Phase-Transfer Dihydroxylation Reaction

Riaz A. Bhunnoo, Yulai Hu, Dramane I. Lainé, Richard C. D. Brown

Journal:

Angewandte Chemie International Edition

Année:

2002

Langue:

english

Fichier:

PDF, 57 KB

english, 2002

5

Highly Diastereoselective Oxy-Michael Additions of Enantiopure δ-Lactol Anions to Nitroalkenes: Asymmetric Synthesis of 1,2-Amino Alcohols

Nicola J. Adderley, David J. Buchanan, Darren J. Dixon, Dramane I. Lainé

Journal:

Angewandte Chemie

Année:

2003

Langue:

english

Fichier:

PDF, 112 KB

english, 2003

6

Highly Diastereoselective Oxy-Michael Additions of Enantiopure δ-Lactol Anions to Nitroalkenes: Asymmetric Synthesis of 1,2-Amino Alcohols

Nicola J. Adderley, David J. Buchanan, Darren J. Dixon, Dramane I. Lainé

Journal:

Angewandte Chemie International Edition

Année:

2003

Langue:

english

Fichier:

PDF, 112 KB

english, 2003

7

ChemInform Abstract: Dispiroketals in Synthesis. Part 24. Preparation and Use of Chiral 2,2′-Bis(triisopropylsilyloxymethyl)bi(dihydropyran)s as New Protecting and Resolving Agents for 1,2-Diols.

Dramane Laine, Morifumi Fujita, Steven V. Ley

Journal:

Année:

1999

Fichier:

PDF, 36 KB

1999

8

ChemInform Abstract: Dispiroketals in Synthesis. Part 25. Further Reactions of Dispiroketal Protected Glycolate to Afford Optically Active 1,2,3,4-Tetraols.

Morifumi Fujita, Dramane Laine, Steven V. Ley

Journal:

Année:

1999

Fichier:

PDF, 37 KB

1999

9

An Asymmetric Phase-Transfer Dihydroxylation Reaction.

Riaz A. Bhunnoo, Yulai Hu, Dramane I. Laine, Richard C. D. Brown

Journal:

Année:

2003

Fichier:

PDF, 112 KB

2003

10

Highly Diastereoselective Oxy-Michael Additions of Enantiopure δ-Lactol Anions to Nitroalkenes: Asymmetric Synthesis of 1,2-Amino Alcohols.

Nicola J. Adderley, David J. Buchanan, Darren J. Dixon, Dramane I. Laine

Journal:

Année:

2003

Fichier:

PDF, 155 KB

2003

11

Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes

Richard M. Angell, Tony D. Angell, Paul Bamborough, Mark J. Bamford, Chun-wa Chung, Stuart G. Cockerill, Stephen S. Flack, Katherine L. Jones, Dramane I. Laine, Timothy Longstaff, Steve Ludbrook, Rosa

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 609 KB

english, 2008

12

Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists

Dramane I. Lainé, Haibo Xie, Noémie Buffet, James J. Foley, Peter Buckley, Edward F. Webb, Katherine L. Widdowson, Michael R. Palovich, Kristen E. Belmonte

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 113 KB

english, 2007

13

Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity

Richard Angell, Nicola M. Aston, Paul Bamborough, Jacky B. Buckton, Stuart Cockerill, Suzanne J. deBoeck, Chris D. Edwards, Duncan S. Holmes, Katherine L. Jones, Dramane I. Laine, Shila Patel, Penny A

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 358 KB

english, 2008

14

Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD

Zehong Wan, Dramane I. Laine, Hongxing Yan, Chongjie Zhu, Katherine L. Widdowson, Peter T. Buckley, Miriam Burman, James J. Foley, Henry M. Sarau, Dulcie B. Schmidt, Edward F. Webb, Kristen E. Belmont

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 388 KB

english, 2009

15

Short asymmetric syntheses of bioactive β-aryl ethanolamine derivatives via the highly diastereoselective delta lactol oxy-Michael addition

David J. Buchanan, Darren J. Dixon, Mark S. Scott, Dramane I. Lainé

Journal:

Tetrahedron: Asymmetry

Année:

2004

Langue:

english

Fichier:

PDF, 244 KB

english, 2004

16

Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists

Lainé, Dramane I., McCleland, Brent, Thomas, Sonia, Neipp, Christopher, Underwood, Brian, Dufour, Jeremy, Widdowson, Katherine L., Palovich, Michael R., Blaney, Frank E., Foley, James J., Webb, Edwar

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2009

17

Synthesis of the non-adjacent bis-THF core of cis-sylvaticin using a double oxidative cyclisation

Bhunnoo, Riaz A., Hobbs, Heather, Lainé, Dramane I., Light, Mark E., Brown, Richard C. D.

Journal:

Organic & Biomolecular Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 335 KB

english, 2009

18

Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C

Lainé, Dramane, Palovich, Michael, McCleland, Brent, Petitjean, Emilie, Delhom, Isabelle, Xie, Haibo, Deng, Jianghe, Lin, Guoliang, Davis, Roderick, Jolit, Anais, Nevins, Neysa, Zhao, Baoguang, Villa

Journal:

ACS Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 2.02 MB

english, 2011

19

Dispiroketals in synthesis. Part 25.1 Further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols

Fujita, Morifumi, Lainé, Dramane, Ley, Steven V.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Année:

1999

Langue:

english

Fichier:

PDF, 324 KB

english, 1999

20

Dispiroketals in synthesis. Part 24.1 Preparation and use of chiral 2,2′-bis(triisopropylsilyloxymethyl)bi(dihydropyran)s as new protecting and resolving agents for 1,2-diols

Lainé, Dramane, Fujita, Morifumi, Ley, Steven V.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Année:

1999

Langue:

english

Fichier:

PDF, 222 KB

english, 1999

21

Inhibitors of cathepsin C (dipeptidyl peptidase I)

Laine, Dramane I, Busch-Petersen, Jakob

Journal:

Expert Opinion on Therapeutic Patents

Année:

2010

Langue:

english

Fichier:

PDF, 395 KB

english, 2010

22

Long-acting muscarinic antagonists for the treatment of chronic obstructive pulmonary disease

Lainé, Dramane I

Journal:

Expert Review of Clinical Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 2.13 MB

english, 2010

23

Indium

Lainé, Dramane

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 57 KB

english, 1999

24

Inhaled long-acting muscarinic antagonists in chronic obstructive pulmonary disease

Busch-Petersen, Jakob, Lainé, Dramane I

Journal:

Future Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 949 KB

english, 2011

25

Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma

Phillips, Jonathan E., Renteria, Lorena, Burns, Lisa, Harris, Paul, Peng, Ruoqi, Bauer, Carla M.T., Laine, Dramane, Stevenson, Christopher S.

Journal:

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Année:

2016

Langue:

english

Fichier:

PDF, 444 KB

english, 2016